Cytomegalovirus Enterocolitis in Immunocompetent Young Children: A Report of Two Cases and Review of the Literature

Paul K. Sue, Nicole M. Salazar-Austin, Oliver G. McDonald, Arvind Rishi, Toby C Cornish, Ravit Arav-Boger

Research output: Contribution to journalArticle

Abstract

Cytomegalovirus (CMV) causes significant morbidity and mortality in congenitally infected children and immunocompromised hosts. Among healthy individuals, CMV is generally thought to cause mild, self-limited illness. CMV enterocolitis, in particular, is rarely considered among immunocompetent children presenting with diarrhea. We describe 2 cases of invasive CMV colitis in immunocompetent infants presenting with diarrhea and review the literature to date on this topic. Although invasive CMV enterocolitis has been sporadically reported among immunocompetent children, it remains an underrecognized cause of infectious diarrhea in this population and indications for antiviral therapy are lacking. We propose that CMV should be included in the differential diagnosis of intractable diarrhea in immunocompetent children.

Original languageEnglish (US)
Pages (from-to)573-576
Number of pages4
JournalPediatric Infectious Disease Journal
Volume35
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • colitis
  • cytomegalovirus
  • enterocolitis
  • gastroenteritis
  • immunocompetent
  • pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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