Cytomegalovirus acquisition and inflammation in human immunodeficiency virus-exposed uninfected Zimbabwean infants

Ceri Evans, Bernard Chasekwa, Sandra Rukobo, Margaret Govha, Kuda Mutasa, Robert Ntozini, Jean H. Humphrey, Andrew J. Prendergast

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV) acquisition and inflammation were evaluated in 231 human immunodeficiency virus (HIV)-exposed uninfected (HEU) and 100 HIV-unexposed Zimbabwean infants aged 6 weeks. The HEU and HIVunexposed infants had a similarly high prevalence of CMV (81.4% vs 74.0%, respectively; P = .14), but HEU infants had higher CMV loads (P = .005) and >2-fold higher C-reactive protein (CRP) concentrations (P < .0001). The CMV-positive HEU infants had higher CRP than the CMV-negative HEU infants; this association disappeared after adjusting for maternal HIV load. Overall, CMV acquisition is high in early life, but HEU infants have higher CMV loads and a proinflammatory milieu, which may be driven partly by maternal HIV viremia.

Original languageEnglish (US)
Pages (from-to)698-702
Number of pages5
JournalJournal of Infectious Diseases
Volume215
Issue number5
StatePublished - Jan 1 2017

Keywords

  • Africa
  • Cytomegalovirus
  • HIV-exposed uninfected infants
  • Immune activation
  • Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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