Cytokinesis through biochemical-mechanical feedback loops

Alexandra Surcel, Yee Seir Kee, Tianzhi Luo, Douglas Robinson

Research output: Contribution to journalArticle

Abstract

Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number9
DOIs
StatePublished - Dec 2010

Fingerprint

Physiological Feedback
Cytokinesis
Dictyostelium
Cytoplasm

Keywords

  • Actin
  • Cell mechanics
  • Control system
  • Cytokinesis
  • Mechanosensing
  • Myosin II

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Cytokinesis through biochemical-mechanical feedback loops. / Surcel, Alexandra; Kee, Yee Seir; Luo, Tianzhi; Robinson, Douglas.

In: Seminars in Cell and Developmental Biology, Vol. 21, No. 9, 12.2010, p. 866-873.

Research output: Contribution to journalArticle

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