Abstract
Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility.
Original language | English (US) |
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Pages (from-to) | 866-873 |
Number of pages | 8 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 21 |
Issue number | 9 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Actin
- Cell mechanics
- Control system
- Cytokinesis
- Mechanosensing
- Myosin II
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology