Cytokinesis mechanics and mechanosensing

Hoku West-Foyle; Douglas N. Robinson

doi:10.1002/cm.21045

Cytokinesis mechanics and mechanosensing

Hoku West-Foyle, Douglas N. Robinson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Cytokinesis shape change occurs through the interfacing of three modules, cell mechanics, myosin II-mediated contractile stress generation and sensing, and a control system of regulatory proteins, which together ensure flexibility and robustness. This integrated system then defines the stereotypical shape changes of successful cytokinesis, which occurs under a diversity of mechanical contexts and environmental conditions.

Original language	English (US)
Pages (from-to)	700-709
Number of pages	10
Journal	Cytoskeleton
Volume	69
Issue number	10
DOIs	https://doi.org/10.1002/cm.21045
State	Published - Oct 2012

Keywords

Actin network
Contractility
Control system
Feedback
Mechanosensing
Myosin II

ASJC Scopus subject areas

Structural Biology
Cell Biology

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10.1002/cm.21045

Cite this

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abstract = "Cytokinesis shape change occurs through the interfacing of three modules, cell mechanics, myosin II-mediated contractile stress generation and sensing, and a control system of regulatory proteins, which together ensure flexibility and robustness. This integrated system then defines the stereotypical shape changes of successful cytokinesis, which occurs under a diversity of mechanical contexts and environmental conditions.",

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AB - Cytokinesis shape change occurs through the interfacing of three modules, cell mechanics, myosin II-mediated contractile stress generation and sensing, and a control system of regulatory proteins, which together ensure flexibility and robustness. This integrated system then defines the stereotypical shape changes of successful cytokinesis, which occurs under a diversity of mechanical contexts and environmental conditions.

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KW - Control system

KW - Feedback

KW - Mechanosensing

KW - Myosin II

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Cytokinesis mechanics and mechanosensing

Abstract

Keywords

ASJC Scopus subject areas

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