Cytokines in the stools of children with complicated shigellosis

T. Azim, R. Chandra Halder, M. Safiullah Sarker, S. Ahmed, J. hamadani, A. Chowdhurry, F. Qadri, M. Abdus Salam, R. Bradley Sack, M. John Albert

Research output: Contribution to journalArticlepeer-review

Abstract

The pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-α in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool TL-6 and TNF-α concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and < 0.001, respectively) or in uninfected children (P < 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-α in stool.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume2
Issue number4
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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