Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

Fatemeh Rajaii, Allison N. McCoy, Terry J. Smith

Research output: Contribution to journalArticle

Abstract

The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalExpert Review of Ophthalmology
Volume9
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Graves Ophthalmopathy
Cytokines
Eye Manifestations
Therapeutics
Interleukin-17
Graves Disease
Autoimmune Diseases
Interleukin-6
Pharmaceutical Preparations

Keywords

  • Autoimmunity
  • Cytokines
  • Graves' disease
  • Graves' orbitopathy
  • Inflammation
  • Interleukins
  • Thyroid-associated ophthalmopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Biomedical Engineering
  • Optometry

Cite this

Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy : From bench to bedside. / Rajaii, Fatemeh; McCoy, Allison N.; Smith, Terry J.

In: Expert Review of Ophthalmology, Vol. 9, No. 3, 2014, p. 227-234.

Research output: Contribution to journalArticle

@article{90e7d535e1764d35baddad4c1dbba481,
title = "Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside",
abstract = "The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.",
keywords = "Autoimmunity, Cytokines, Graves' disease, Graves' orbitopathy, Inflammation, Interleukins, Thyroid-associated ophthalmopathy",
author = "Fatemeh Rajaii and McCoy, {Allison N.} and Smith, {Terry J.}",
year = "2014",
doi = "10.1586/17469899.2014.917960",
language = "English (US)",
volume = "9",
pages = "227--234",
journal = "Expert Review of Respiratory Medicine",
issn = "1747-6348",
publisher = "Expert Reviews Ltd.",
number = "3",

}

TY - JOUR

T1 - Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy

T2 - From bench to bedside

AU - Rajaii, Fatemeh

AU - McCoy, Allison N.

AU - Smith, Terry J.

PY - 2014

Y1 - 2014

N2 - The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

AB - The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

KW - Autoimmunity

KW - Cytokines

KW - Graves' disease

KW - Graves' orbitopathy

KW - Inflammation

KW - Interleukins

KW - Thyroid-associated ophthalmopathy

UR - http://www.scopus.com/inward/record.url?scp=84901280800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901280800&partnerID=8YFLogxK

U2 - 10.1586/17469899.2014.917960

DO - 10.1586/17469899.2014.917960

M3 - Article

AN - SCOPUS:84901280800

VL - 9

SP - 227

EP - 234

JO - Expert Review of Respiratory Medicine

JF - Expert Review of Respiratory Medicine

SN - 1747-6348

IS - 3

ER -