Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

Fatemeh Rajaii; Allison N. McCoy; Terry J. Smith

doi:10.1586/17469899.2014.917960

Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

Fatemeh Rajaii, Allison N. McCoy, Terry J. Smith

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

Original language	English (US)
Pages (from-to)	227-234
Number of pages	8
Journal	Expert Review of Ophthalmology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1586/17469899.2014.917960
State	Published - Jun 2014
Externally published	Yes

Keywords

Autoimmunity
Cytokines
Graves' disease
Graves' orbitopathy
Inflammation
Interleukins
Thyroid-associated ophthalmopathy

ASJC Scopus subject areas

Biomedical Engineering
Ophthalmology
Optometry

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10.1586/17469899.2014.917960

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@article{90e7d535e1764d35baddad4c1dbba481,

title = "Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside",

abstract = "The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.",

keywords = "Autoimmunity, Cytokines, Graves' disease, Graves' orbitopathy, Inflammation, Interleukins, Thyroid-associated ophthalmopathy",

author = "Fatemeh Rajaii and McCoy, {Allison N.} and Smith, {Terry J.}",

note = "Funding Information: This work was supported in part by National Institutes of Health grants EY008976, EY011708, DK063121, Center for Vision grant EY007003 from the NEI, an unrestricted grant from Research to Prevent Blindness, and the Bell Charitable Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2014",

month = jun,

doi = "10.1586/17469899.2014.917960",

language = "English (US)",

volume = "9",

pages = "227--234",

journal = "Expert Review of Ophthalmology",

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publisher = "Taylor and Francis Ltd.",

number = "3",

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T1 - Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy

T2 - From bench to bedside

AU - Rajaii, Fatemeh

AU - McCoy, Allison N.

AU - Smith, Terry J.

N1 - Funding Information: This work was supported in part by National Institutes of Health grants EY008976, EY011708, DK063121, Center for Vision grant EY007003 from the NEI, an unrestricted grant from Research to Prevent Blindness, and the Bell Charitable Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2014/6

Y1 - 2014/6

N2 - The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

AB - The pathophysiology underlying Graves' disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is not completely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of specific cytokine pathway inhibitors for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, the authors review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as IL-6, TNF-α, and IL-17 pathways to TAO, and explore the potential of targeting these pathways for therapy.

KW - Autoimmunity

KW - Cytokines

KW - Graves' disease

KW - Graves' orbitopathy

KW - Inflammation

KW - Interleukins

KW - Thyroid-associated ophthalmopathy

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JO - Expert Review of Ophthalmology

JF - Expert Review of Ophthalmology

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Cytokines as villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

Abstract

Keywords

ASJC Scopus subject areas

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