Cytokine imbalance in acute coronary syndrome

Samir E. Alam, Samer S. Nasser, Khaled E. Fernainy, Aida A. Habib, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

The excessive mortality of coronary heart disease is attributed primarily to rupture and thrombotic transformation of the atherosclerotic plaque. Inflammation plays a critical role in plaque destabilization and vulnerability. Inflammation is not confined to the culprit segment but is convincingly widespread in the coronary and remote vascular beds. Systemic inflammatory, thrombotic and hemodynamic factors are relevant to the pathological and clinical outcome. In addition to their fundamental role in thrombosis, there is ample evidence that platelets contribute significantly to promoting plaque inflammation. A new paradigm of unbalanced cytokine-mediated inflammation is emerging, providing diagnostic and therapeutic opportunity for intervention. Amplifying intrinsic anti-inflammatory mechanisms constitutes attractive avenues for future investigation.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume4
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

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Acute Coronary Syndrome
Cytokines
Inflammation
Atherosclerotic Plaques
Coronary Disease
Blood Vessels
Rupture
Thrombosis
Anti-Inflammatory Agents
Blood Platelets
Hemodynamics
Mortality
Therapeutics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Alam, S. E., Nasser, S. S., Fernainy, K. E., Habib, A. A., & Badr, K. F. (2004). Cytokine imbalance in acute coronary syndrome. Current Opinion in Pharmacology, 4(2), 166-170. https://doi.org/10.1016/j.coph.2003.10.011

Cytokine imbalance in acute coronary syndrome. / Alam, Samir E.; Nasser, Samer S.; Fernainy, Khaled E.; Habib, Aida A.; Badr, Kamal F.

In: Current Opinion in Pharmacology, Vol. 4, No. 2, 04.2004, p. 166-170.

Research output: Contribution to journalArticle

Alam, SE, Nasser, SS, Fernainy, KE, Habib, AA & Badr, KF 2004, 'Cytokine imbalance in acute coronary syndrome', Current Opinion in Pharmacology, vol. 4, no. 2, pp. 166-170. https://doi.org/10.1016/j.coph.2003.10.011
Alam SE, Nasser SS, Fernainy KE, Habib AA, Badr KF. Cytokine imbalance in acute coronary syndrome. Current Opinion in Pharmacology. 2004 Apr;4(2):166-170. https://doi.org/10.1016/j.coph.2003.10.011
Alam, Samir E. ; Nasser, Samer S. ; Fernainy, Khaled E. ; Habib, Aida A. ; Badr, Kamal F. / Cytokine imbalance in acute coronary syndrome. In: Current Opinion in Pharmacology. 2004 ; Vol. 4, No. 2. pp. 166-170.
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