Cytogenetics of human malignant melanoma

Jeffrey M. Trent

Research output: Contribution to journalArticlepeer-review

Abstract

There has been a tremendous recent resurgence of interest in examining chromosomal abnormalities in human cancers (particularly solid tumors). This interest has been stimulated by the molecular examination of recurring chromosome abnormalities, and the recognition that they may pinpoint the location of growth regulatory sequences (e.g. cellular oncogenes). This finding coupled with the clear recognition that specific chromosome abnormalities can also have important diagnostic and prognostic implications, have caused this avenue of research to expand at a significant rate. The following brief review will summarize the current state of knowledge regarding recurring chromosome abnormalities in human malignant melanoma. A discussion of chromosome changes in pre-malignant skin lesions, primary melanoma, and metastatic melanoma is described. Brief descriptions of the potential clinical utility, and biologic relevance of chromosome abnormalities in this disorder are also discussed.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalCANCER AND METASTASIS REVIEW
Volume10
Issue number2
DOIs
StatePublished - Jun 1991
Externally publishedYes

Keywords

  • cytogenetics
  • malignant melanoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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