TY - JOUR
T1 - Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma
AU - Rosenblum-Vos, Lynne S.
AU - Meltzer, Stephen J.
AU - Leana-Cox, Julie
AU - Schwartz, Stuart
N1 - Funding Information:
We thank Dr. Mark J. Krasna for supplying surgical specimens, Dr. Benjamin E Trump for pathology results, and Elizabeth O. Waters and Jeffrey W. Strovel for expert technical assistance. This work was supported in part by grants from the American Cancer Society (PDT-419) and the Office of Research and Development, Medical Research Services, Department of Veterans Affairs.
PY - 1993/10/15
Y1 - 1993/10/15
N2 - Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.
AB - Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.
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U2 - 10.1016/0165-4608(93)90182-L
DO - 10.1016/0165-4608(93)90182-L
M3 - Article
C2 - 8242593
AN - SCOPUS:0027490921
SN - 0165-4608
VL - 70
SP - 127
EP - 131
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -