Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma

Lynne S. Rosenblum-Vos, Stephen J. Meltzer, Julie Leana-Cox, Stuart Schwartz

Research output: Contribution to journalArticle

Abstract

Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume70
Issue number2
DOIs
StatePublished - Oct 15 1993
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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