Cytogenetic analysis of posterior uveal melanoma

Rodney N. Wiltshire, Victor M. Elner, Thomas Dennis, Andrew K. Vine, Jeffrey M. Trent

Research output: Contribution to journalArticle

Abstract

Cytogenetic analysis was performed on short-term cultures of primary tumor samples from seven patients with posterior uveal melanoma. Informative data were obtained from four patients, all of whom had a near-diploid chromosomal number and clonal chromosomal alterations. Analysis of one patient's tumor revealed monosomy 3 as the only cytogenetically distinguishable aberration. Trisomies of chromosome 8 and i(8)(q10) were detected in two other patients in combination with monosomy of chromosome 3. The fourth patient's karyotype displayed two different translocations. One translocation, der(6)t(6;8)(q12;q13.1), resulted in the over-representation of 8q13.1→qter and a partial monosomy of 6q12→qter; the other translocation, der(9)t(6;9)(p12;p23), produced a partial trisomy of 6p12→pter and a partial monosomy of 9p23→pter. These results support the view that the recurring pattern of chromosomal rearrangements in ocular melanoma is unique from that associated with cutaneous malignant melanoma. Furthermore, these results help confirm that chromosomes 3, 6, and 8 are nonrandomly altered in ocular melanoma.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume66
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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Cytogenetic Analysis
Monosomy
Chromosome Deletion
Chromosomes, Human, Pair 3
Melanoma
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 6
Trisomy
Diploidy
Karyotype
Neoplasms
Uveal melanoma

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Wiltshire, R. N., Elner, V. M., Dennis, T., Vine, A. K., & Trent, J. M. (1993). Cytogenetic analysis of posterior uveal melanoma. Cancer Genetics and Cytogenetics, 66(1), 47-53. https://doi.org/10.1016/0165-4608(93)90148-F

Cytogenetic analysis of posterior uveal melanoma. / Wiltshire, Rodney N.; Elner, Victor M.; Dennis, Thomas; Vine, Andrew K.; Trent, Jeffrey M.

In: Cancer Genetics and Cytogenetics, Vol. 66, No. 1, 1993, p. 47-53.

Research output: Contribution to journalArticle

Wiltshire, RN, Elner, VM, Dennis, T, Vine, AK & Trent, JM 1993, 'Cytogenetic analysis of posterior uveal melanoma', Cancer Genetics and Cytogenetics, vol. 66, no. 1, pp. 47-53. https://doi.org/10.1016/0165-4608(93)90148-F
Wiltshire, Rodney N. ; Elner, Victor M. ; Dennis, Thomas ; Vine, Andrew K. ; Trent, Jeffrey M. / Cytogenetic analysis of posterior uveal melanoma. In: Cancer Genetics and Cytogenetics. 1993 ; Vol. 66, No. 1. pp. 47-53.
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