Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: A meta-analysis

Theodoros N. Sergentanis, Konstantinos P. Economopoulos, Souzana Choussein, Nikos F. Vlahos

    Research output: Contribution to journalArticle

    Abstract

    This meta-analysis aims to examine whether the genotype status of MspI, Ile462Val, and Thr461Asn polymorphisms in Cytochrome P450 1A1 (CYP1A1) is associated with ovarian cancer risk. Eligible case-control studies were identified through search in MEDLINE (end of search: October 2010). Pooled odds ratios (ORs) were appropriately derived from fixed effects or random effects models. Concerning MspI polymorphism, seven studies were eligible (1,051 cases and 1,613 controls); 11 studies were eligible (1,680 cases and 3,345 controls) for Ile462- Val and three studies were eligible (349 cases and 785 controls) for Thr461Asn. Ile462Val polymorphism seemed to confer elevated ovarian cancer risk concerning homozygous carriers (pooled OR = 2.65, 95% CI: 1.40-5.03, p = 0.003, fixed effects), as well as at the recessive model (pooled OR = 2.10, 95% CI: 1.13-3.92, p = 0.020, fixed effects); these findings were replicated upon Caucasian subjects. MspI polymorphism was not associated with ovarian cancer risk (for heterozygous TC vs TT carriers pooled OR = 1.10, 95% CI: 0.91-1.34, p = 0.329, fixed effects; for homozygous CC vs. TT carriers pooled OR = 1.11, 95% CI: 0.65-1.90, p = 0.693, fixed effects). With respect to Thr461Asn polymorphism a finding of borderline statistical significance emerged, pointing to marginally elevated ovarian cancer risk in heterozygous Thr/Asn carriers (pooled OR = 1.62, 95% CI: 0.97-2.70, p = 0.066, fixed effects), but not in homozygous Asn/Asn carriers (pooled OR = 1.40, 95% CI: 0.18-10.89, p = 0.749, fixed effects). Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians. Additional case-control studies of high methodological quality are needed in order to further substantiate and enrich the present findings. Special attention should be paid upon the design of future studies; Asian and African populations should represent points of focus.

    Original languageEnglish (US)
    Pages (from-to)9921-9930
    Number of pages10
    JournalMolecular Biology Reports
    Volume39
    Issue number11
    DOIs
    StatePublished - Nov 1 2012

    Keywords

    • Cytochrome P450 1A1
    • Ile462Val polymorphism
    • MspI polymorphism
    • Ovarian cancer
    • Thr461Asn polymorphism

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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  • Cite this

    Sergentanis, T. N., Economopoulos, K. P., Choussein, S., & Vlahos, N. F. (2012). Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: A meta-analysis. Molecular Biology Reports, 39(11), 9921-9930. https://doi.org/10.1007/s11033-012-1860-0