Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: A meta-analysis

Theodoros N. Sergentanis, Konstantinos P. Economopoulos, Souzana Choussein, Nikos F. Vlahos

    Research output: Contribution to journalArticlepeer-review

    Abstract

    This meta-analysis aims to examine whether the genotype status of MspI and Ile462Val polymorphisms in Cytochrome-P450 1A1 (CYP1A1) is associated with cervical cancer risk. Eligible case-control studies were identified through search in MEDLINE (end of search: October 2010). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random effects models. Concerning MspI polymorphism, six studies were eligible (722 cases and 770 controls); four studies were eligible (350 cases and 519 controls) for Ile462Val. MspI polymorphism was associated with elevated cervical cancer risk (for heterozygous TC vs. TT carriers OR = 1.50, 95% CI: 0.93-2.42, random effects; for homozygous CC vs. TT carriers OR = 2.66, 95% CI: 1.14-6.19, random effects). Similarly, Ile462Val polymorphism was associated with elevated cervical cancer risk (for heterozygous Ile/Val vs. Ile/Ile carriers OR = 2.36, 95% CI: 1.10-5.08, random effects; for homozygous Val/Val vs. Ile/Ile carriers OR = 2.73, 95% CI: 1.21-6.15, fixed effects). The results were replicated upon Caucasian subjects, who represented the majority of existing data. The two examined CYP1A1 genotype polymorphisms seem to confer additional risk for cervical cancer. Accumulation of further data seems mandatory for future race-specific analyses and for the demonstration of CYP1A1-smoking interactions.

    Original languageEnglish (US)
    Pages (from-to)6647-6654
    Number of pages8
    JournalMolecular Biology Reports
    Volume39
    Issue number6
    DOIs
    StatePublished - Jun 1 2012

    Keywords

    • Cervical cancer
    • Cytochrome-P450 1A1
    • Ile462Val polymorphism
    • MspI polymorphism

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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