Cytochrome P-450 mediated metabolism in active murine systemic lupus erythematosus

A. N. Baer, F. A. Green

Research output: Contribution to journalArticlepeer-review

Abstract

In a comparison of NZB/NZW female mice either with active systemic lupus erythematosus (SLE) (28-33 weeks of age) or without overt SLE (7-13 weeks), the hepatic microsomal activities of ethoxycoumarin O-deethylation and aminopyrine N-demethylation were decreased 32% (p < 0.05) and 28% (p < 0.03), respectively, and cytochrome P-450 levels were decreased 34% (p < 0.01) in the mice with active SLE. These changes were not associated with age differences alone in 2 nonautoimmune strains. Active murine SLE is thus associated with significant depressions in both hepatic cytochrome P-450 levels and microsomal enzyme activities. The metabolism of drugs and endogenous substrates may thus be impaired in active SLE.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalJournal of Rheumatology
Volume16
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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