Abstract
In a comparison of NZB/NZW female mice either with active systemic lupus erythematosus (SLE) (28-33 weeks of age) or without overt SLE (7-13 weeks), the hepatic microsomal activities of ethoxycoumarin O-deethylation and aminopyrine N-demethylation were decreased 32% (p < 0.05) and 28% (p < 0.03), respectively, and cytochrome P-450 levels were decreased 34% (p < 0.01) in the mice with active SLE. These changes were not associated with age differences alone in 2 nonautoimmune strains. Active murine SLE is thus associated with significant depressions in both hepatic cytochrome P-450 levels and microsomal enzyme activities. The metabolism of drugs and endogenous substrates may thus be impaired in active SLE.
Original language | English (US) |
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Pages (from-to) | 335-338 |
Number of pages | 4 |
Journal | Journal of Rheumatology |
Volume | 16 |
Issue number | 3 |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology