Cystic pancreatic neuroendocrine tumors: Is preoperative diagnosis possible?

Steven A. Ahrendt, Richard A. Komorowski, Michael J. Demeure, Stuart D. Wilson, Henry A. Pitt

Research output: Contribution to journalArticle

Abstract

Pancreatic neuroendocrine tumors rarely undergo cystic degeneration leading to a radiologic appearance, which is often interpreted as a pancreatic mucinous cystadenoma or pseudocyst. We reviewed our experience with 38 neuroendocrine tumors, four of which were cystic, and 24 other cystic pancreatic tumors (mucinous cystadenoma [n = 5], cystadenocarcinoma [n = 6], serous cystadenoma [n = 3], solid/cystic papillary neoplasm [n = 3], intraductal papillary mucinous tumor [n = 6], and mucinous adenocarcinoma [n = 1]) managed operatively between 1990 and 2000. This review was undertaken to identify clinical and pathologic features useful for preoperative diagnosis of cystic neuroendocrine tumors. Two of the four patients with cystic neuroendocrine tumors presented with abdominal pain, one patient was asymptomatic, and one patient had hypoglycemia. Three of the four cystic neuroendocrine tumors were identified by CT scan, and none were biopsied preoperatively. Preoperative diagnoses included mucinous cystadenoma in two patients (n = 2), pancreatic cystic neoplasm in one patient, (n = 1) and insulinoma in one patient (n = 1). All four cystic neuroendocrine tumors were benign and were completely resected (distal pancreatectomy [n = 2], enucleation [n = 2]). Cystic neuroendocrine tumors are difficult to diagnose preoperatively because the majority of these tumors are nonfunctional, and CT does not differentiate these tumors from other cystic neoplasms. Cystic neuroendocrine tumors represent a subgroup of pancreatic cystic and neuroendocrine tumors with malignant potential. Their high resectability rate further supports the role of surgical exploration and resection in the treatment of pancreatic cystic neoplasms.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume6
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Neuroendocrine Tumors
Mucinous Cystadenoma
Neoplasms
Pancreatic Neoplasms
Serous Cystadenoma
Cystadenocarcinoma
Mucinous Adenocarcinoma
Insulinoma
Pancreatectomy
Hypoglycemia
Abdominal Pain

Keywords

  • Pancreatic cystic neoplasm
  • Pancreatic islet cell tumor
  • Pancreatic neoplasm
  • Pancreatic neuroendocrine tumor
  • Pancreatic surgery

ASJC Scopus subject areas

  • Surgery

Cite this

Ahrendt, S. A., Komorowski, R. A., Demeure, M. J., Wilson, S. D., & Pitt, H. A. (2002). Cystic pancreatic neuroendocrine tumors: Is preoperative diagnosis possible? Journal of Gastrointestinal Surgery, 6(1), 66-74. https://doi.org/10.1016/S1091-255X(01)00020-8

Cystic pancreatic neuroendocrine tumors : Is preoperative diagnosis possible? / Ahrendt, Steven A.; Komorowski, Richard A.; Demeure, Michael J.; Wilson, Stuart D.; Pitt, Henry A.

In: Journal of Gastrointestinal Surgery, Vol. 6, No. 1, 2002, p. 66-74.

Research output: Contribution to journalArticle

Ahrendt, Steven A. ; Komorowski, Richard A. ; Demeure, Michael J. ; Wilson, Stuart D. ; Pitt, Henry A. / Cystic pancreatic neuroendocrine tumors : Is preoperative diagnosis possible?. In: Journal of Gastrointestinal Surgery. 2002 ; Vol. 6, No. 1. pp. 66-74.
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abstract = "Pancreatic neuroendocrine tumors rarely undergo cystic degeneration leading to a radiologic appearance, which is often interpreted as a pancreatic mucinous cystadenoma or pseudocyst. We reviewed our experience with 38 neuroendocrine tumors, four of which were cystic, and 24 other cystic pancreatic tumors (mucinous cystadenoma [n = 5], cystadenocarcinoma [n = 6], serous cystadenoma [n = 3], solid/cystic papillary neoplasm [n = 3], intraductal papillary mucinous tumor [n = 6], and mucinous adenocarcinoma [n = 1]) managed operatively between 1990 and 2000. This review was undertaken to identify clinical and pathologic features useful for preoperative diagnosis of cystic neuroendocrine tumors. Two of the four patients with cystic neuroendocrine tumors presented with abdominal pain, one patient was asymptomatic, and one patient had hypoglycemia. Three of the four cystic neuroendocrine tumors were identified by CT scan, and none were biopsied preoperatively. Preoperative diagnoses included mucinous cystadenoma in two patients (n = 2), pancreatic cystic neoplasm in one patient, (n = 1) and insulinoma in one patient (n = 1). All four cystic neuroendocrine tumors were benign and were completely resected (distal pancreatectomy [n = 2], enucleation [n = 2]). Cystic neuroendocrine tumors are difficult to diagnose preoperatively because the majority of these tumors are nonfunctional, and CT does not differentiate these tumors from other cystic neoplasms. Cystic neuroendocrine tumors represent a subgroup of pancreatic cystic and neuroendocrine tumors with malignant potential. Their high resectability rate further supports the role of surgical exploration and resection in the treatment of pancreatic cystic neoplasms.",
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