Cystic fibrosis lung transplantation

Andrew T. Braun, Christian A. Merlo

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: This review summarizes recently published investigations on issues pertaining to cystic fibrosis (CF) lung transplantation. We specifically focus on indications and candidate selection as well as infectious and noninfectious issues specific to CF lung transplant recipients. Recent Findings: Recent studies have focused on candidate adequacy in high-risk CF patients. We review the current literature on individuals who develop respiratory failure requiring mechanical ventilation and those patients with a pretransplant diagnosis of pulmonary hypertension. Furthermore, the management of peri-operative infectious issues is reviewed including recurrent infections with multidrug-resistant bacterial, mycobacterial, and fungal organisms. Other CF-specific issues addressed include common comorbidities such as CF-related diabetes, gastroesophageal reflux, CF liver disease, and bone metabolism. Summary: Lung transplantation is a limited, but potentially life-saving therapeutic option for patients with CF. Optimal candidate selection and awareness of CF-specific issues in the pretransplant and posttransplant setting may lead to better long-term outcomes.

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalCurrent opinion in pulmonary medicine
Volume17
Issue number6
DOIs
StatePublished - Nov 2011

Keywords

  • cystic fibrosis
  • lung transplantation
  • mechanical ventilation
  • organ allocation
  • transplant candidacy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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