Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation

Marc Peters-Golden, Anthony P. Sampson, William Henderson, Stephen Holgate, Mark Liu, Redwan Moqbel, Hans Bisgaard, Stephen Peters, Reynold Panettieri, Qutayba Hamid

Research output: Contribution to journalArticle

Abstract

Unexpected aspects of the antiasthmatic efficacy of leukotriene modifiers and glucocorticosteroids have been observed. For both classes, the observed effects may be partially explainable on the basis of underrecognized interactions involving leukotrienes. This review examines the interactions between leukotrienes and other mediators of asthma. It details the effects of glucocorticosteroids on leukotriene synthesis and on leukocyte populations in asthmatic airways. Unexpected controller effects of the leukotriene modifiers may reflect the fact that leukotrienes and other mediators of asthma, such as TH2 cytokines, positively influence each other's generation. The ability of the leukotriene modifiers to disrupt such extensive interactions means that other relevant mediators are targeted indirectly by leukotriene blockade. Among asthma therapies, the glucocorticosteroids have numerous anti-inflammatory activities, but their effects may be unpredictable. Many processes involved in inflammation appear to escape modulation by glucocorticosteroids, including leukotriene synthesis, and leukotriene generation is among them. Understanding whether glucocorticosteroids reduce cysteinyl leukotriene levels in the airway is important in determining the clinical value of combining glucocorticosteroid therapy with leukotriene modifier therapy.

Original languageEnglish (US)
Pages (from-to)S37-S48
JournalJournal of Allergy and Clinical Immunology
Volume111
Issue number1 SUPPL.
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Keywords

  • Asthmatic airway
  • Cysteinyl leukotrienes
  • Glucocorticosteroids
  • Leukocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Peters-Golden, M., Sampson, A. P., Henderson, W., Holgate, S., Liu, M., Moqbel, R., Bisgaard, H., Peters, S., Panettieri, R., & Hamid, Q. (2003). Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation. Journal of Allergy and Clinical Immunology, 111(1 SUPPL.), S37-S48. https://doi.org/10.1067/mai.2003.23