Cystatin C as a marker of cognitive function in elders

Findings from the Health ABC Study

Kristine Yaffe, Karla Lindquist, Michael G. Shlipak, Eleanor Marie Simonsick, Linda Fried, Caterina Rosano, Suzanne Satterfield, Hal Atkinson, B. Gwen Windham, Manjula Kurella-Tamura

Research output: Contribution to journalArticle

Abstract

We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

Original languageEnglish (US)
Pages (from-to)798-802
Number of pages5
JournalAnnals of Neurology
Volume63
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Cystatin C
Cognition
Health
Odds Ratio
Confidence Intervals
Amyloid
Kidney
Brain
Serum
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yaffe, K., Lindquist, K., Shlipak, M. G., Simonsick, E. M., Fried, L., Rosano, C., ... Kurella-Tamura, M. (2008). Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study. Annals of Neurology, 63(6), 798-802. https://doi.org/10.1002/ana.21383

Cystatin C as a marker of cognitive function in elders : Findings from the Health ABC Study. / Yaffe, Kristine; Lindquist, Karla; Shlipak, Michael G.; Simonsick, Eleanor Marie; Fried, Linda; Rosano, Caterina; Satterfield, Suzanne; Atkinson, Hal; Windham, B. Gwen; Kurella-Tamura, Manjula.

In: Annals of Neurology, Vol. 63, No. 6, 06.2008, p. 798-802.

Research output: Contribution to journalArticle

Yaffe, K, Lindquist, K, Shlipak, MG, Simonsick, EM, Fried, L, Rosano, C, Satterfield, S, Atkinson, H, Windham, BG & Kurella-Tamura, M 2008, 'Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study', Annals of Neurology, vol. 63, no. 6, pp. 798-802. https://doi.org/10.1002/ana.21383
Yaffe, Kristine ; Lindquist, Karla ; Shlipak, Michael G. ; Simonsick, Eleanor Marie ; Fried, Linda ; Rosano, Caterina ; Satterfield, Suzanne ; Atkinson, Hal ; Windham, B. Gwen ; Kurella-Tamura, Manjula. / Cystatin C as a marker of cognitive function in elders : Findings from the Health ABC Study. In: Annals of Neurology. 2008 ; Vol. 63, No. 6. pp. 798-802.
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