Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study

Kristine Yaffe; Karla Lindquist; Michael G. Shlipak; Eleanot Simonsick; Linda Fried; Caterina Rosano; Suzanne Satterfield; Hal Atkinson; B. Gwen Windham; Manjula Kurella-Tamura

doi:10.1002/ana.21383

Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study

Kristine Yaffe, Karla Lindquist, Michael G. Shlipak, Eleanot Simonsick, Linda Fried, Caterina Rosano, Suzanne Satterfield, Hal Atkinson, B. Gwen Windham, Manjula Kurella-Tamura

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

Original language	English (US)
Pages (from-to)	798-802
Number of pages	5
Journal	Annals of neurology
Volume	63
Issue number	6
DOIs	https://doi.org/10.1002/ana.21383
State	Published - Jun 2008
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study",

abstract = "We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).",

author = "Kristine Yaffe and Karla Lindquist and Shlipak, {Michael G.} and Eleanot Simonsick and Linda Fried and Caterina Rosano and Suzanne Satterfield and Hal Atkinson and Windham, {B. Gwen} and Manjula Kurella-Tamura",

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AU - Yaffe, Kristine

AU - Lindquist, Karla

AU - Shlipak, Michael G.

AU - Simonsick, Eleanot

AU - Fried, Linda

AU - Rosano, Caterina

AU - Satterfield, Suzanne

AU - Atkinson, Hal

AU - Windham, B. Gwen

AU - Kurella-Tamura, Manjula

PY - 2008/6

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N2 - We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

AB - We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

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Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study

Abstract

ASJC Scopus subject areas

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