Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study

Kristine Yaffe, Karla Lindquist, Michael G. Shlipak, Eleanot Simonsick, Linda Fried, Caterina Rosano, Suzanne Satterfield, Hal Atkinson, B. Gwen Windham, Manjula Kurella-Tamura

Research output: Contribution to journalArticle

Abstract

We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

Original languageEnglish (US)
Pages (from-to)798-802
Number of pages5
JournalAnnals of neurology
Volume63
Issue number6
DOIs
StatePublished - Jun 1 2008

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Yaffe, K., Lindquist, K., Shlipak, M. G., Simonsick, E., Fried, L., Rosano, C., Satterfield, S., Atkinson, H., Windham, B. G., & Kurella-Tamura, M. (2008). Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study. Annals of neurology, 63(6), 798-802. https://doi.org/10.1002/ana.21383