Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study

Kristine Yaffe, Karla Lindquist, Michael G. Shlipak, Eleanor Marie Simonsick, Linda Fried, Caterina Rosano, Suzanne Satterfield, Hal Atkinson, B. Gwen Windham, Manjula Kurella-Tamura

Research output: Contribution to journalArticle

Abstract

We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain β-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p ≤ 0.02) compared with those with intermediate/low level and 7 years greater decline (p ≤ 0.04). Incident cognitive impairment (decline ≥1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

Original languageEnglish (US)
Pages (from-to)798-802
Number of pages5
JournalAnnals of Neurology
Volume63
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Cystatin C
Cognition
Health
Odds Ratio
Confidence Intervals
Amyloid
Kidney
Brain
Serum
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yaffe, K., Lindquist, K., Shlipak, M. G., Simonsick, E. M., Fried, L., Rosano, C., ... Kurella-Tamura, M. (2008). Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study. Annals of Neurology, 63(6), 798-802. https://doi.org/10.1002/ana.21383

Cystatin C as a marker of cognitive function in elders : Findings from the Health ABC Study. / Yaffe, Kristine; Lindquist, Karla; Shlipak, Michael G.; Simonsick, Eleanor Marie; Fried, Linda; Rosano, Caterina; Satterfield, Suzanne; Atkinson, Hal; Windham, B. Gwen; Kurella-Tamura, Manjula.

In: Annals of Neurology, Vol. 63, No. 6, 06.2008, p. 798-802.

Research output: Contribution to journalArticle

Yaffe, K, Lindquist, K, Shlipak, MG, Simonsick, EM, Fried, L, Rosano, C, Satterfield, S, Atkinson, H, Windham, BG & Kurella-Tamura, M 2008, 'Cystatin C as a marker of cognitive function in elders: Findings from the Health ABC Study', Annals of Neurology, vol. 63, no. 6, pp. 798-802. https://doi.org/10.1002/ana.21383
Yaffe, Kristine ; Lindquist, Karla ; Shlipak, Michael G. ; Simonsick, Eleanor Marie ; Fried, Linda ; Rosano, Caterina ; Satterfield, Suzanne ; Atkinson, Hal ; Windham, B. Gwen ; Kurella-Tamura, Manjula. / Cystatin C as a marker of cognitive function in elders : Findings from the Health ABC Study. In: Annals of Neurology. 2008 ; Vol. 63, No. 6. pp. 798-802.
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