Cyr61 is a potential prognostic marker for prostate cancer

Naoki Terada, Prakash Kulkarni, Robert H. Getzenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Cysteine-rich angiogenic inducer 61 (Cyr61) is an extracellular matrix protein involved in the transduction of growth factor and hormone signaling that is frequently altered in expression in several types of cancers. In prostate cancer (PCa), Cyr61 is highly expressed in organ-confined disease. Further, Cyr61 expression levels are associated with a lower risk of disease recurrence, and can be quantitatively measured in the serum. Considered together, these results indicate that Cyr61 is a potential and clinically useful tissue, as well as serum-based biomarker for differentiating lethal and non-lethal PCa.

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalAsian Journal of Andrology
Volume14
Issue number3
DOIs
StatePublished - May 2012

Keywords

  • Cyr61
  • lethal prostate cancer
  • non-lethal prostate cancer
  • overdiagnosis
  • overtreatment
  • prostate cancer

ASJC Scopus subject areas

  • Urology

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