CYP19A1 polymorphisms are associated with bone mineral density in Chinese men

Xiumei Hong, Yi Hsiang Hsu, Henry Terwedow, Lester M. Arguelles, Genfu Tang, Xue Liu, Shanchun Zhang, Xin Xu, Xiping Xu

Research output: Contribution to journalArticle

Abstract

Aromatase-dependent biosynthesis of estrogen plays an important role in maintenance of the male skeleton, and Cytochrome p450 aromatase is the key enzyme to catalyze the conversion of androgen precursors to estrogens. We investigated the association of polymorphisms in the CYP19A1 gene and bone mineral density in a Chinese cohort. 2392 extreme low femoral neck BMD cases or extreme high femoral neck BMD controls were selected from a population-based cohort and genotyped for eight SNPs in the CYP19A1 gene. Significant associations for rs17703883, rs12594287 and rs16964201 SNPs with BMD were found in men only. Men with TC/CC genotypes in the rs17703883 SNP had a 1.5 times higher risk of having extreme low femoral neck BMD (P = 0.003, empirical P value = 0.05), and decreased BMDs at total body (P = 0.004, empirical P value = 0.07) and total hip (P = 0.003, empirical P value = 0.05). Men carrying AA/AG genotypes in the rs12594287 SNP had a 30% reduced risk of having extreme low femoral neck BMD (P = 0.007, empirical P value = 0.12), and increased BMDs at total body (P = 0.0009, empirical P value = 0.018) and total hip (P = 0.001, empirical P value = 0.02). Men carrying TT/TC genotypes in the rs16964201 SNP had a 40% reduced risk of having extreme low femoral neck BMD (P = 0.005, empirical P value = 0.087), and increased BMDs at total body (P = 0.0001, empirical P value = 0.002) and total hip (P = 0.0006, empirical P value = 0.012). Haplotype analysis showed that the G-C-T-A-T haplotype was significantly related to higher BMD. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women.

Original languageEnglish (US)
Pages (from-to)491-500
Number of pages10
JournalHuman Genetics
Volume121
Issue number3-4
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Femur Neck
Bone Density
Single Nucleotide Polymorphism
Hip
Aromatase
Genotype
Haplotypes
Estrogens
Genes
Skeleton
Cytochrome P-450 Enzyme System
Androgens
Maintenance
Enzymes
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Hong, X., Hsu, Y. H., Terwedow, H., Arguelles, L. M., Tang, G., Liu, X., ... Xu, X. (2007). CYP19A1 polymorphisms are associated with bone mineral density in Chinese men. Human Genetics, 121(3-4), 491-500. https://doi.org/10.1007/s00439-006-0303-1

CYP19A1 polymorphisms are associated with bone mineral density in Chinese men. / Hong, Xiumei; Hsu, Yi Hsiang; Terwedow, Henry; Arguelles, Lester M.; Tang, Genfu; Liu, Xue; Zhang, Shanchun; Xu, Xin; Xu, Xiping.

In: Human Genetics, Vol. 121, No. 3-4, 05.2007, p. 491-500.

Research output: Contribution to journalArticle

Hong, X, Hsu, YH, Terwedow, H, Arguelles, LM, Tang, G, Liu, X, Zhang, S, Xu, X & Xu, X 2007, 'CYP19A1 polymorphisms are associated with bone mineral density in Chinese men', Human Genetics, vol. 121, no. 3-4, pp. 491-500. https://doi.org/10.1007/s00439-006-0303-1
Hong, Xiumei ; Hsu, Yi Hsiang ; Terwedow, Henry ; Arguelles, Lester M. ; Tang, Genfu ; Liu, Xue ; Zhang, Shanchun ; Xu, Xin ; Xu, Xiping. / CYP19A1 polymorphisms are associated with bone mineral density in Chinese men. In: Human Genetics. 2007 ; Vol. 121, No. 3-4. pp. 491-500.
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AU - Tang, Genfu

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