CYP17A1 enzyme activity is linked to ambulatory blood pressure in a family-based population study

Daniel Ackermann, Menno Pruijm, Belen Ponte, Idris Guessous, Georg Ehret, Geneviève Escher, Bernhard Dick, Heba Al-Alwan, Philippe Vuistiner, Fred Paccaud, Michel Burnier, Antoinette Péchère-Bertschi, Pierre Yves Martin, Bruno Vogt, Markus Mohaupt, Murielle Bochud

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synthesizing enzyme 17α-hydroxylase (CYP17A1) to blood pressure (BP). We hypothesized that the genetic signal may translate into a correlation of ambulatory BP (ABP) with apparent CYP17A1 activity in a family-based population study and estimated the heritability of CYP17A1 activity. METHODS: In the Swiss Kidney Project on Genes in Hypertension, day and night urinary excretions of steroid hormone metabolites were measured in 518 participants (220 men, 298 women), randomly selected from the general population. CYP17A1 activity was assessed by 2 ratios of urinary steroid metabolites: one estimating the combined 17α-hydroxylase/17,20-lyase activity (ratio 1) and the other predominantly 17α-hydroxylase activity (ratio 2). A mixed linear model was used to investigate the association of ABP with log-transformed CYP17A1 activities exploring effect modification by urinary sodium excretion. RESULTS: Daytime ABP was positively associated with ratio 1 under conditions of high, but not low urinary sodium excretion (P interaction

Original languageEnglish (US)
Pages (from-to)484-493
Number of pages10
JournalAmerican Journal of Hypertension
Volume29
Issue number4
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Aging
  • Blood pressure
  • CYP17A1
  • Heritability
  • Hypertension
  • Salt
  • Steroids

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Ackermann, D., Pruijm, M., Ponte, B., Guessous, I., Ehret, G., Escher, G., Dick, B., Al-Alwan, H., Vuistiner, P., Paccaud, F., Burnier, M., Péchère-Bertschi, A., Martin, P. Y., Vogt, B., Mohaupt, M., & Bochud, M. (2016). CYP17A1 enzyme activity is linked to ambulatory blood pressure in a family-based population study. American Journal of Hypertension, 29(4), 484-493. https://doi.org/10.1093/ajh/hpv138