CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis

Gurkan Bozdag, Aslan Alp, Zeynep Saribas, Selcuk Tuncer, Tarik Aksu, Timur Gurgan

Research output: Contribution to journalArticle

Abstract

Endometriosis seems to be the result of a complex interaction between environmental factors and various genes. In this regard, the cytochrome subfamily 17 (CYP17) may play an important role by altering the biosynthesis of sex steroids. CYP2C19 is also an important member of the cytochrome P450 (CYP) family, and related mutations may result in an inability to fully metabolize environmental chemicals and cytokines, leading to several diseases. This study sought to determine whether there is a relationship between endometriosis and CYP17 T>C, CYP2C19*2 and CYP2C19*3 polymorphisms. When samples from 46 patients with endometriosis and 39 healthy controls were analysed, A2A2 type mutation of the CYP17 gene was observed to be more frequent in patients with endometriosis (34.8 versus 7.7%, P = 0.003). No association was found between the severity of endometriosis and CYP2C19*2 or CYP2C19*3 polymorphisms of the CYP2C19 gene. These results suggest that mutations related with sex steroid metabolism seem to have an important role in endometriosis. However, the relation between detoxification ability and endometriosis should be examined in further studies with larger sample sizes.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalReproductive biomedicine online
Volume20
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • CYP17
  • CYP2C19
  • Cytochrome p450
  • Endometriosis
  • Gene polymorphism

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Fingerprint Dive into the research topics of 'CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis'. Together they form a unique fingerprint.

  • Cite this

    Bozdag, G., Alp, A., Saribas, Z., Tuncer, S., Aksu, T., & Gurgan, T. (2010). CYP17 and CYP2C19 gene polymorphisms in patients with endometriosis. Reproductive biomedicine online, 20(2), 286-290. https://doi.org/10.1016/j.rbmo.2009.11.007