TY - JOUR
T1 - Cyclosporine-induced hypotension
AU - Parkhurst, George W.
AU - Moon, Byong H.
AU - Xia, Rinlin
AU - Littleton, Marguerite T.
AU - Prancan, Arthur V.
PY - 1989/11
Y1 - 1989/11
N2 - The cardiovascular effects of i.v. infusion of cyclosporine were studied in pentobarbital-anesthetized rabbits. In doses ranging from 0.5 to 120 mg/kg/hr, CsA induced significant, sustained, dose-dependent hypotension. At the 60 mg/kg/hr dose the average drop in diastolic blood pressure was 27 mmHg (n = 9). Possible mechanisms were investigated by comparison of heart rate and blood pressure responses to physiologic manipulation, metabolic inhibition, or receptor antagonism before and after infusion of CsA. CsA did not modify responses to vagal stimulation, decreases in heart rate and blood pressure, P<0.001 and P<0.002, respectively. However, the cardiovascular reflex response during recovery was significantly attenuated after CsA infusion, P<0.05, n = 7. Response to bilateral carotid occlusion after CsA was decreased by 17 mmHg (n = 8, P<0.01). There were no significant differences between CsA alone and CsA plus glycopyrrolate or CsA plus aspirin. In this cyclosporine-induced hypotensive rabbit model, the hypotensive response appears to be related to a decrease in the endogenous sympathetic adrenergic activity, not to alterations in cholinergic tone, ganglionic transmission, or vasodilatory prostaglandin metabolis.
AB - The cardiovascular effects of i.v. infusion of cyclosporine were studied in pentobarbital-anesthetized rabbits. In doses ranging from 0.5 to 120 mg/kg/hr, CsA induced significant, sustained, dose-dependent hypotension. At the 60 mg/kg/hr dose the average drop in diastolic blood pressure was 27 mmHg (n = 9). Possible mechanisms were investigated by comparison of heart rate and blood pressure responses to physiologic manipulation, metabolic inhibition, or receptor antagonism before and after infusion of CsA. CsA did not modify responses to vagal stimulation, decreases in heart rate and blood pressure, P<0.001 and P<0.002, respectively. However, the cardiovascular reflex response during recovery was significantly attenuated after CsA infusion, P<0.05, n = 7. Response to bilateral carotid occlusion after CsA was decreased by 17 mmHg (n = 8, P<0.01). There were no significant differences between CsA alone and CsA plus glycopyrrolate or CsA plus aspirin. In this cyclosporine-induced hypotensive rabbit model, the hypotensive response appears to be related to a decrease in the endogenous sympathetic adrenergic activity, not to alterations in cholinergic tone, ganglionic transmission, or vasodilatory prostaglandin metabolis.
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U2 - 10.1097/00007890-198911000-00006
DO - 10.1097/00007890-198911000-00006
M3 - Article
C2 - 2815248
AN - SCOPUS:0024325537
SN - 0041-1337
VL - 48
SP - 756
EP - 759
JO - Transplantation
JF - Transplantation
IS - 5
ER -