Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells

H. J. Broxterman, H. M. Pinedo, G. J. Schuurhuis, J. Lankelma

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclosporin A (Sandimmune®) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady-state 3H-cyclosporin A accumulation at 37°C in 2780AD cells was 60-70% of that in the sensitive A2780 cells. A rapid increase of ATP consumption and lactate production was induced in 2780AD cells by verapamil, but not by cyclosporin A. These results suggest that the interactions of cyclosporin A and verapamil with P-glycoprotein, which leads to inhibition of drug transport, have a different mechanistic basis.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
JournalBritish Journal of Cancer
Volume62
Issue number1
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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