Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility

Michele Tavecchio, Sofia Lisanti, Aaron Lam, Jagadish C. Ghosh, Nina M. Martin, Michael O'Connell, Ashani T. Weeraratna, Andrew V. Kossenkov, Louise C. Showe, Dario C. Altieri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Signals originated from mitochondria can affect other intracellular compartments. Results: Decreased levels in mitochondrial cyclophilin D promote cell proliferation and cell motility via chemokine/STAT3 signaling. Conclusion: Mitochondria regulate nuclear gene expression. Significance: Interorganelle signaling affects cell proliferation and cell motility.

Original languageEnglish (US)
Pages (from-to)5553-5561
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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