Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility

Michele Tavecchio; Sofia Lisanti; Aaron Lam; Jagadish C. Ghosh; Nina M. Martin; Michael O'Connell; Ashani T. Weeraratna; Andrew V. Kossenkov; Louise C. Showe; Dario C. Altieri

doi:10.1074/jbc.M112.433045

Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility

Michele Tavecchio, Sofia Lisanti, Aaron Lam, Jagadish C. Ghosh, Nina M. Martin, Michael O'Connell, Ashani T. Weeraratna, Andrew V. Kossenkov, Louise C. Showe, Dario C. Altieri

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Background: Signals originated from mitochondria can affect other intracellular compartments. Results: Decreased levels in mitochondrial cyclophilin D promote cell proliferation and cell motility via chemokine/STAT3 signaling. Conclusion: Mitochondria regulate nuclear gene expression. Significance: Interorganelle signaling affects cell proliferation and cell motility.

Original language	English (US)
Pages (from-to)	5553-5561
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.433045
State	Published - Feb 22 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.433045

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title = "Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility",

abstract = "Background: Signals originated from mitochondria can affect other intracellular compartments. Results: Decreased levels in mitochondrial cyclophilin D promote cell proliferation and cell motility via chemokine/STAT3 signaling. Conclusion: Mitochondria regulate nuclear gene expression. Significance: Interorganelle signaling affects cell proliferation and cell motility.",

author = "Michele Tavecchio and Sofia Lisanti and Aaron Lam and Ghosh, {Jagadish C.} and Martin, {Nina M.} and Michael O'Connell and Weeraratna, {Ashani T.} and Kossenkov, {Andrew V.} and Showe, {Louise C.} and Altieri, {Dario C.}",

year = "2013",

month = feb,

day = "22",

doi = "10.1074/jbc.M112.433045",

language = "English (US)",

volume = "288",

pages = "5553--5561",

journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility

AU - Tavecchio, Michele

AU - Lisanti, Sofia

AU - Lam, Aaron

AU - Ghosh, Jagadish C.

AU - Martin, Nina M.

AU - O'Connell, Michael

AU - Weeraratna, Ashani T.

AU - Kossenkov, Andrew V.

AU - Showe, Louise C.

AU - Altieri, Dario C.

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: Signals originated from mitochondria can affect other intracellular compartments. Results: Decreased levels in mitochondrial cyclophilin D promote cell proliferation and cell motility via chemokine/STAT3 signaling. Conclusion: Mitochondria regulate nuclear gene expression. Significance: Interorganelle signaling affects cell proliferation and cell motility.

AB - Background: Signals originated from mitochondria can affect other intracellular compartments. Results: Decreased levels in mitochondrial cyclophilin D promote cell proliferation and cell motility via chemokine/STAT3 signaling. Conclusion: Mitochondria regulate nuclear gene expression. Significance: Interorganelle signaling affects cell proliferation and cell motility.

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DO - 10.1074/jbc.M112.433045

M3 - Article

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AN - SCOPUS:84874326984

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EP - 5561

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Cyclophilin d extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility

Abstract

ASJC Scopus subject areas

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