Cyclooxygenase mediated airway response to leukotriene D4 in the cat

G. B. Graybar, J. K. Harrington, K. H. Cowen, Ernst W Spannhake, A. L. Hyman, D. B. McNamara, P. J. Kadowitz

Research output: Contribution to journalArticle

Abstract

The effects of leukotriene D4 (LTD4) on pulmonary mechanics were investigated in anesthetized, paralyzed cats under conditions of controlled ventilation. Intravenous injections of LTD4 in doses of 3, 10, and 30 μg caused significant increases in transpulmonary pressure (PTP) and lung resistance (RL) while decreasing dynamic compliance (Cdyn). LTD4 also increased systemic arterial pressure (PA0). The changes in PTP, RL, and Cdyn in response to LTD4 were blocked by sodium meclofenamate, a cyclooxygenase inhibitor. However, there was no significant change in the increase in PA0 following cyclooxygenase blockade. U 46619, a thromboxane mimic, was 30 to 100 times more potent than LTD4 in increasing PTP, RL and decreasing Cdyn in the cat. These data show that LTD4 has significant smooth muscle constrictor activity in central airways as well as peripheral portions of the feline lung. In addition, these data suggest that in the cat the actions of intravenously administered LTD4 on lung mechanics are mediated by release of cyclooxygenase products while the systemic pressor effects are not dependent upon the integrity of the cyclooxygenase pathway.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalProstaglandins
Volume31
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Leukotriene D4
Prostaglandin-Endoperoxide Synthases
Cats
Lung
Mechanics
Meclofenamic Acid
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Cyclooxygenase Inhibitors
Thromboxanes
Felidae
Intravenous Injections
Compliance
Ventilation
Smooth Muscle
Muscle
Arterial Pressure
Pressure

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Graybar, G. B., Harrington, J. K., Cowen, K. H., Spannhake, E. W., Hyman, A. L., McNamara, D. B., & Kadowitz, P. J. (1986). Cyclooxygenase mediated airway response to leukotriene D4 in the cat. Prostaglandins, 31(1), 167-177. https://doi.org/10.1016/0090-6980(86)90234-0

Cyclooxygenase mediated airway response to leukotriene D4 in the cat. / Graybar, G. B.; Harrington, J. K.; Cowen, K. H.; Spannhake, Ernst W; Hyman, A. L.; McNamara, D. B.; Kadowitz, P. J.

In: Prostaglandins, Vol. 31, No. 1, 1986, p. 167-177.

Research output: Contribution to journalArticle

Graybar, GB, Harrington, JK, Cowen, KH, Spannhake, EW, Hyman, AL, McNamara, DB & Kadowitz, PJ 1986, 'Cyclooxygenase mediated airway response to leukotriene D4 in the cat', Prostaglandins, vol. 31, no. 1, pp. 167-177. https://doi.org/10.1016/0090-6980(86)90234-0
Graybar, G. B. ; Harrington, J. K. ; Cowen, K. H. ; Spannhake, Ernst W ; Hyman, A. L. ; McNamara, D. B. ; Kadowitz, P. J. / Cyclooxygenase mediated airway response to leukotriene D4 in the cat. In: Prostaglandins. 1986 ; Vol. 31, No. 1. pp. 167-177.
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