Cyclolinopeptides and their analogs - A new family of peptide immunosuppressants affecting the calcineurin system

Ignacy Z. Siemion, Marek Cebrat, Zbigniew Wieczorek

Research output: Contribution to journalArticle

Abstract

The results of the investigation of immunosuppressive activity of cyclolinopeptide A (CLA - cyclic hydrophobic nonapeptide present in the linseeds) and its analogs are discussed. The results obtained for other natural cyclic peptides showing structural similarities with CLA (antamanide, cycloamanides, hymenistatin, hymenamides) are also reviewed. It results from these investigations that the molecular mechanism of the CLA action is the same as that of cyclosporin A and FK-506 compound, i.e. it consists in formation of the complex with cyclophilin and inhibition - in this form - of the phosphatase activity of calcineurin. The results also suggest that the immunosuppressive activity of these compounds resides in their -Pro-Xxx-Phe- fragment, where Xxx is a hydrophobic (e.g. Leu, Val) or aromatic amino acid residue.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume47
Issue number3
StatePublished - 1999
Externally publishedYes

Keywords

  • Antamanide
  • Cycloamanides
  • Cyclolinopeptide A
  • Hymenamides, hymenistatin
  • Peptide immunosuppressants

ASJC Scopus subject areas

  • Immunology

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