Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Kaicheng Liang, Zhao Wang, Osman O. Ahsen, Hsiang Chieh Lee, Benjamin M. Potsaid, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Xingde Li, James G. Fujimoto

Research output: Contribution to journalArticle

Abstract

Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging. We demonstrate a new cycloid scanner in a tethered capsule for ultrahigh speed, side-viewing optical coherence tomography (OCT) endomicroscopy in vivo. The cycloid capsule incorporates two scanners: a piezoelectrically actuated resonant fiber scanner to perform a precision, small FOV, fast scan and a micromotor scanner to perform a wide FOV, slow scan. Together these scanners distally scan the beam circumferentially in a 2D cycloid pattern, generating an unwrapped1 mm× 38 mm strip FOV. Sequential strip volumes can be acquired with proximal pullback to image centimeter-long regions. Using ultrahigh speed 1.3 μm wavelength swept-source OCT at a 1.17 MHz axial scan rate, we imaged the human rectum at 3 volumes/s. Each OCT strip volume had 166 × 2322 axial scans with 8.5 μm axial and 30 μm transverse resolution. We further demonstrate OCT angiography at 0.5 volumes/s, producing volumetric images of vasculature. In addition to OCT applications, cycloid scanning promises to enable precision 2D optical scanning for other imaging modalities, including fluorescence confocal and nonlinear microscopy.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalOptica
Volume5
Issue number1
DOIs
StatePublished - Jan 20 2018

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo'. Together they form a unique fingerprint.

  • Cite this

    Liang, K., Wang, Z., Ahsen, O. O., Lee, H. C., Potsaid, B. M., Jayaraman, V., Cable, A., Mashimo, H., Li, X., & Fujimoto, J. G. (2018). Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo. Optica, 5(1), 36-43. https://doi.org/10.1364/OPTICA.5.000036