Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor - An aid in differential diagnosis

Tsui Lien Mao, Jeff D. Seidman, Robert J Kurman, Ie Ming Shih

Research output: Contribution to journalArticle

Abstract

Epithelioid trophoblastic tumor (ETT) is a relatively uncommon trophoblastic tumor that can be confused with several trophoblastic and nontrophoblastic lesions, notably the placental site nodule and invasive squamous carcinoma of the cervix. In this report, we analyzed the immunoreactivity of two cell cycle-regulated proteins, cyclin E and p16, in ETTs, placental site nodules and cervical squamous carcinomas to determine whether they are useful in their differential diagnosis. Other trophoblastic lesions were also evaluated. Using an H-score based on both percentage of positively stained cells and immunointensity, we found that ETTs demonstrated a much higher cyclin E staining score than placental site nodules (P40. Only two placental site nodules had scores above the cutoff and both showed morphologic features that placed them in an intermediate position between a typical placental site nodule and an ETT, so-called "atypical PSN." p16 immunoreactivity, was not detected in any of the ETTs and placental site nodules, whereas it was strongly and diffusely positive in the vast majority of cervical squamous carcinomas examined (83/87 cases) (P

Original languageEnglish (US)
Pages (from-to)1105-1110
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number9
DOIs
StatePublished - Sep 2006

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Trophoblastic Neoplasms
Cyclin E
Squamous Cell Carcinoma
Differential Diagnosis
Cell Cycle Proteins
Cervix Uteri
Staining and Labeling

Keywords

  • Cervical squamous carcinoma
  • Cyclin E
  • Epithelioid trophoblastic tumor
  • p16
  • Placental site nodule

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor - An aid in differential diagnosis. / Mao, Tsui Lien; Seidman, Jeff D.; Kurman, Robert J; Shih, Ie Ming.

In: American Journal of Surgical Pathology, Vol. 30, No. 9, 09.2006, p. 1105-1110.

Research output: Contribution to journalArticle

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