TY - JOUR
T1 - Cyclin-dependent kinase and initiation at eukaryotic origins
T2 - A replication switch?
AU - Jallepalli, Prasad V.
AU - Kelly, Thomas J.
PY - 1997/6
Y1 - 1997/6
N2 - A growing body of evidence indicates that cyclin-dependent kinases (CDKs) regulate the activity of eukaryotic origins of replication both positively and negatively. Although the details of this control remain unclear, recent work suggests that CDKs act directly at origins, where they associate with and phosphorylate several key initiator proteins. These data suggest that a CDK-regulated replication switch operates at each origin to ensure that initiation occurs precisely once per cell cycle.
AB - A growing body of evidence indicates that cyclin-dependent kinases (CDKs) regulate the activity of eukaryotic origins of replication both positively and negatively. Although the details of this control remain unclear, recent work suggests that CDKs act directly at origins, where they associate with and phosphorylate several key initiator proteins. These data suggest that a CDK-regulated replication switch operates at each origin to ensure that initiation occurs precisely once per cell cycle.
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U2 - 10.1016/S0955-0674(97)80008-7
DO - 10.1016/S0955-0674(97)80008-7
M3 - Article
C2 - 9159077
AN - SCOPUS:0030906338
SN - 0955-0674
VL - 9
SP - 358
EP - 363
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -