Cyclin D1 splice variant and risk for non-Hodgkin lymphoma

Sophia S. Wang, Wendy Cozen, Richard K. Severson, Patricia Hartge, James R. Cerhan, Scott Davis, Robert Welch, Nathaniel Rothman, Stephen J. Chanock

Research output: Contribution to journalArticle

Abstract

To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalHuman genetics
Volume120
Issue number2
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Wang, S. S., Cozen, W., Severson, R. K., Hartge, P., Cerhan, J. R., Davis, S., Welch, R., Rothman, N., & Chanock, S. J. (2006). Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. Human genetics, 120(2), 297-300. https://doi.org/10.1007/s00439-006-0212-3