Cyclin A links c-Myc to adhesion-independent cell proliferation

John F. Barrett; Brian C. Lewis; Arthur T. Hoang; Rene J. Alvarez; Chi V. Dang

doi:10.1074/jbc.270.27.15923

Cyclin A links c-Myc to adhesion-independent cell proliferation

John F. Barrett, Brian C. Lewis, Arthur T. Hoang, Rene J. Alvarez, Chi V. Dang

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

Original language	English (US)
Pages (from-to)	15923-15925
Number of pages	3
Journal	Journal of Biological Chemistry
Volume	270
Issue number	27
DOIs	https://doi.org/10.1074/jbc.270.27.15923
State	Published - Jul 7 1995

ASJC Scopus subject areas

Biochemistry

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title = "Cyclin A links c-Myc to adhesion-independent cell proliferation",

abstract = "Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.",

author = "Barrett, {John F.} and Lewis, {Brian C.} and Hoang, {Arthur T.} and Alvarez, {Rene J.} and Dang, {Chi V.}",

year = "1995",

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doi = "10.1074/jbc.270.27.15923",

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AU - Lewis, Brian C.

AU - Hoang, Arthur T.

AU - Alvarez, Rene J.

AU - Dang, Chi V.

PY - 1995/7/7

Y1 - 1995/7/7

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AB - Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

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