Cyclin A links c-Myc to adhesion-independent cell proliferation

John F. Barrett; Brian C. Lewis; Arthur T. Hoang; Rene J. Alvarez; Chi V. Dang

doi:10.1074/jbc.270.27.15923

Cyclin A links c-Myc to adhesion-independent cell proliferation

John F. Barrett, Brian C. Lewis, Arthur T. Hoang, Rene J. Alvarez, Chi V. Dang

School of Medicine

Research output: Contribution to journal › Article

Abstract

Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

Original language	English (US)
Pages (from-to)	15923-15925
Number of pages	3
Journal	Journal of Biological Chemistry
Volume	270
Issue number	27
DOIs	https://doi.org/10.1074/jbc.270.27.15923
Publication status	Published - Jul 7 1995

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ASJC Scopus subject areas

Biochemistry

Cite this

Barrett, J. F., Lewis, B. C., Hoang, A. T., Alvarez, R. J., & Dang, C. V. (1995). Cyclin A links c-Myc to adhesion-independent cell proliferation. Journal of Biological Chemistry, 270(27), 15923-15925. https://doi.org/10.1074/jbc.270.27.15923

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Access to Document

10.1074/jbc.270.27.15923