Abstract
Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.
Original language | English (US) |
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Pages (from-to) | 15923-15925 |
Number of pages | 3 |
Journal | Journal of Biological Chemistry |
Volume | 270 |
Issue number | 27 |
DOIs | |
State | Published - Jul 7 1995 |
ASJC Scopus subject areas
- Biochemistry