Cyclin A links c-Myc to adhesion-independent cell proliferation

John F. Barrett, Brian C. Lewis, Arthur T. Hoang, Rene J. Alvarez, Chi V. Dang

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat la fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c- Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.

Original languageEnglish (US)
Pages (from-to)15923-15925
Number of pages3
JournalJournal of Biological Chemistry
Issue number27
StatePublished - Jul 7 1995

ASJC Scopus subject areas

  • Biochemistry


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