Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity

Jeffrey N. Keller, Keith B. Hanni, Mark P. Mattson, William R. Markesbery

Research output: Contribution to journalArticle


Recent studies suggest that increased lipid peroxidation and lipid peroxidation products, such as 4-hydroxynonenal (HNE), contribute to neuronal loss in conditions associated with oxidative stress. The focus of the present study was to determine possible neuroprotective effects of elevated cyclic nucleotide levels against lipid peroxidation and HNE-mediated neural toxicity. Application of 8-bromo derivative analogs of cAMP or cGMP resulted in attenuation of HNE-induced increases in mitochondrial calcium, reactive oxygen species, and neuron loss. Similar results were obtained when neural cells were pretreated with the phosphodiesterase inhibitors zaprinast or isobutylmethylxanthanine (IBMX). These data are consistent with a possible neuroprotective role for elevated cyclic nucleotide levels in disorders associated with increases in lipid peroxidation and HNE.

Original languageEnglish (US)
Pages (from-to)3731-3734
Number of pages4
Issue number16
StatePublished - Nov 16 1998
Externally publishedYes


  • 4-Hydroxynonenal
  • Cyclic nucleotide
  • Lipid peroxidation
  • Mitochondria
  • Neuron
  • Reactive oxygen species

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Keller, J. N., Hanni, K. B., Mattson, M. P., & Markesbery, W. R. (1998). Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity. NeuroReport, 9(16), 3731-3734.