Cyclic nucleotide-gated ion channels: An extended family with diverse functions

John T. Finn, Maria E. Grunwald, King Wai Yau

Research output: Contribution to journalReview articlepeer-review

Abstract

An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.

Original languageEnglish (US)
Pages (from-to)395-426
Number of pages32
JournalAnnual review of physiology
Volume58
DOIs
StatePublished - 1996

Keywords

  • cGMP ion channel channel gating
  • cyclic- nucleotide binding
  • ligand-gated ion channels
  • permeation and modulation
  • structure and function of ion channels

ASJC Scopus subject areas

  • Physiology

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