TY - JOUR
T1 - Cyclic nucleotide-gated ion channels
T2 - An extended family with diverse functions
AU - Finn, John T.
AU - Grunwald, Maria E.
AU - Yau, King Wai
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
AB - An ion channel directly activated by cGMP was first discovered about ten years ago. Since then, a number of ion channels with the same property (cyclic nucleotide-activated channels) have been reported that are involved in a variety of cell functions. In addition, other channels have been found that are not primarily controlled by cyclic nucleotides but are modulated by them (cyclic nucleotide-modulated channels). These channels likewise have diverse functions and tissue distributions. Both channel classes are reviewed here. Coverage includes the cyclic-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating and modulation, and physiological functions of the channels.
KW - cGMP ion channel channel gating
KW - cyclic- nucleotide binding
KW - ligand-gated ion channels
KW - permeation and modulation
KW - structure and function of ion channels
UR - http://www.scopus.com/inward/record.url?scp=0029979454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029979454&partnerID=8YFLogxK
U2 - 10.1146/annurev.ph.58.030196.002143
DO - 10.1146/annurev.ph.58.030196.002143
M3 - Review article
C2 - 8815801
AN - SCOPUS:0029979454
SN - 0066-4278
VL - 58
SP - 395
EP - 426
JO - Annual review of physiology
JF - Annual review of physiology
ER -