Cyclic AMP phosphodiesterase (EC 184.108.40.206) activity was characterized in an extract of C. albicans. The enzyme showed a pH optimum at 7.5 and was not activated by imidazole or inhibited by theophylline or caffeine. Phosphodiesterase activity of Candida was stimulated by Ca++ and Mg++ and the apparent Km values for cAMP were 4.2 and 250 μM. The enzyme activity was increased during germination and dropped steadily during the pseudohyphal stage of morphogenesis.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Dec 1 1976|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)