Cyclic 3',5' nucleotide phosphodiesterase of Candida albicans

M. Gunasekaran, W. T. Hughes, W. J. Maguire

Research output: Contribution to journalArticle

Abstract

Cyclic AMP phosphodiesterase (EC 3.1.4.17) activity was characterized in an extract of C. albicans. The enzyme showed a pH optimum at 7.5 and was not activated by imidazole or inhibited by theophylline or caffeine. Phosphodiesterase activity of Candida was stimulated by Ca++ and Mg++ and the apparent Km values for cAMP were 4.2 and 250 μM. The enzyme activity was increased during germination and dropped steadily during the pseudohyphal stage of morphogenesis.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalMicrobios Letters
Volume3
Issue number9
StatePublished - 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Microbiology
  • Hematology
  • Pharmacology

Cite this

Gunasekaran, M., Hughes, W. T., & Maguire, W. J. (1976). Cyclic 3',5' nucleotide phosphodiesterase of Candida albicans. Microbios Letters, 3(9), 47-53.