CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

Kimberly N. Kremer, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Haiming Dai, Allan D. Hess, B. Douglas Smith, Christie Rodriguez-Ramirez, Judith E. Karp, Scott H. Kaufmann, Karen E. Hedin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The chemokine receptor CXCR4 plays a role in AML. Results: SDF-1, the ligand of CXCR4, induces apoptosis in AML cell lines and patient samples via modulation of Bcl-2 family members. Conclusion: SDF-1 induces apoptosis of AML cells via up-regulation of Bak and Noxa and down-regulation of Bcl-XL. Significance: SDF-1/CXCR4 signaling could induce AML cell apoptosis if bone marrow survival cues can be disrupted.

Original languageEnglish (US)
Pages (from-to)22899-22914
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - Aug 9 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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