CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

Xueqing Sun, Guangcun Cheng, Mingang Hao, Jianghua Zheng, Xiaoming Zhou, Jian Zhang, Russell S. Taichman, Kenneth J. Pienta, Jianhua Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the trafficking of normal and malignant cells. For many years, it was believed that CXCR4 was the only receptor for CXCL12. Yet, recent work has demonstrated that CXCL12 also binds to another seven-transmembrane span receptor called CXCR7. Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Here, we review the current concepts regarding the role of CXCL12 / CXCR4 / CXCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CXCL12 to develop secondary tumors. We also summarize recent therapeutic approaches to target these receptors and/or their ligands.

Original languageEnglish (US)
Pages (from-to)709-722
Number of pages14
JournalCancer and Metastasis Reviews
Volume29
Issue number4
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • CXCL12 / CXCR4 / CXCR7 chemokine axis
  • Cancer progression
  • Chemokines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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