TY - JOUR
T1 - Cutting edge
T2 - The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt
AU - Lebson, Lori
AU - Gocke, Anne
AU - Rosenzweig, Jason
AU - Alder, Jonathan
AU - Civin, Curt
AU - Calabresi, Peter A.
AU - Whartenby, Katharine A.
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood. Transcription factors play a key role in driving T cells toward specific lineages. We have identified a role for the transcription factor Kruppel-like factor (KLF) 4 in the development of IL-17-producing CD4+ T cells. KLF4 was required for the production of IL-17, and further, chromatin immunoprecipation analysis demonstrated binding of KLF4 to the IL-17 promoter, indicating a direct effect on the regulation of IL-17. Further, KLF4-deficient T cells upregulated expression of retinoic acid-related orphan receptor γt similar to wild-type during the polarization process toward Th17, suggesting that these two transcription factors are regulated independently.
AB - Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood. Transcription factors play a key role in driving T cells toward specific lineages. We have identified a role for the transcription factor Kruppel-like factor (KLF) 4 in the development of IL-17-producing CD4+ T cells. KLF4 was required for the production of IL-17, and further, chromatin immunoprecipation analysis demonstrated binding of KLF4 to the IL-17 promoter, indicating a direct effect on the regulation of IL-17. Further, KLF4-deficient T cells upregulated expression of retinoic acid-related orphan receptor γt similar to wild-type during the polarization process toward Th17, suggesting that these two transcription factors are regulated independently.
UR - http://www.scopus.com/inward/record.url?scp=78650641116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650641116&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1002750
DO - 10.4049/jimmunol.1002750
M3 - Article
C2 - 21076063
AN - SCOPUS:78650641116
VL - 185
SP - 7161
EP - 7164
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 12
ER -