Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp

Arnob Banerjee, Alexander S. Banks, Martijn C. Nawijn, X. Peter Chen, Paul B. Rothman

Research output: Contribution to journalArticle

Abstract

Recent studies have suggested that signaling initiated by the activation of Ag receptors and signaling activated through cytokine receptors may be regulated by a common set of inhibitory proteins. Suppressor of cytokine signaling 3 (SOCS-3), which has previously been demonstrated to inhibit cytokine signaling, is induced on TCR ligation. Overexpression of SOCS-3 can inhibit transcription driven by the IL-2 promoter in response to T cell activation. This inhibitory activity correlates with the suppression of calcineurin-dependent dephosphorylation and activation of the IL-2 promoter binding transcription factor, NFATp. Infection of primary murine T cells with a retrovirus encoding SOCS-3 blocks their IL-2 production in response to activation. Interestingly, SOCS-3 was found to coimmunoprecipitate with the catalytic subunit of calcineurin. These studies suggest that SOCS-3 may regulate T cell function as part of a negative feedback loop.

Original languageEnglish (US)
Pages (from-to)4277-4281
Number of pages5
JournalJournal of Immunology
Volume168
Issue number9
DOIs
StatePublished - May 1 2002

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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