Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

Paul F. Robbins, Mark E. Dudley, John Wunderlich, Mona El-Gamil, Yong F. Li, Juhua Zhou, Jianping Huang, Daniel J. Powell, Steven A. Rosenberg

Research output: Contribution to journalArticlepeer-review

Abstract

The lack of persistence of transferred autologous mature lymphocytes in humans has been a major limitation to the application of effective cell transfer therapies. The results of a pilot clinical trial in 13 patients with metastatic melanoma suggested that conditioning with nonmyeloablative chemotherapy before adoptive transfer of activated tumor-reactive T cells enhances tumor regression and increases the overall rates of objective clinical responses. The present report examines the relationship between T cell persistence and tumor regression through analysis of the TCR β-chain V region gene products expressed in samples obtained from 25 patients treated with this protocol Sequence analysis demonstrated that there was a significant correlation between tumor regression and the degree of persistence in peripheral blood of adoptively transferred T cell clones, suggesting that inadequate T cell persistence may represent a major factor limiting responses to adoptive immunotherapy.

Original languageEnglish (US)
Pages (from-to)7125-7130
Number of pages6
JournalJournal of Immunology
Volume173
Issue number12
DOIs
StatePublished - Dec 15 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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