Cutting edge: Expression of functional CD137 receptor by dendritic cells

Ryan A. Wilcox, Andrei I. Chapoval, Kevin S. Gorski, Mizuto Otsuji, Tahiro Shin, Dallas B. Flies, Koji Tamada, Robert S. Mittler, Haruo Tsuchiya, Drew M. Pardoll, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Interaction between dendritic cells (DCs) and T cells is a prerequisite for the initiation of a T cell response. The molecular nature of this interaction remains to be fully characterized. We report in this work that freshly isolated mouse splenic DCs and bone marrow-derived DCs express CD137 on the cell surface and in soluble form. Triggering CD137 increased the secretion of IL-6 and IL-12 from DCs. More importantly, infusion of an agonistic mAb to CD137 into naive mice enhanced the ability of DCs to stimulate T cell proliferation in response to both alloantigens and a nominal Ag in vitro. This enhancement of DC function is not mediated through activation of T cells, because the effect was also observed in RAG-1 knockout mice that lack T cells. Our findings implicate CD137 as an important receptor involved in the modulation of DC function.

Original languageEnglish (US)
Pages (from-to)4262-4267
Number of pages6
JournalJournal of Immunology
Volume168
Issue number9
DOIs
StatePublished - May 1 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Wilcox, R. A., Chapoval, A. I., Gorski, K. S., Otsuji, M., Shin, T., Flies, D. B., Tamada, K., Mittler, R. S., Tsuchiya, H., Pardoll, D. M., & Chen, L. (2002). Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal of Immunology, 168(9), 4262-4267. https://doi.org/10.4049/jimmunol.168.9.4262