Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models

Dallas B. Flies, Shengdian Wang, Haiying Xu, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Upon interaction with B7 homolog 1, programmed death-1 (PD-1) transmits a critical coinhibitory signal to T cells to negatively regulate immune responses. By extensively searching the genomic database with the IgV region of PD-1, we identified a homolog and named it PD-1 homolog (PD-1H). PD-1H is broadly expressed on the cell surface of hematopoietic cells and could be further upregulated on CD4+ and CD8+ T cells following activation. We have generated an mAb against PD-1H, which strikingly prevents acute graft-versus-host disease in semi- and fully allogeneic murine models, leading to full chimerism following treatment. Graft-versus-host disease remains a primary hindrance to successful allogeneic hematopoietic cell transplantation therapy for the treatment of hematologic malignancy. Therefore, manipulation of PD-1H function may provide a new modality for controlling T cell responses to allogeneic tissues in transplant medicine.

Original languageEnglish (US)
Pages (from-to)1537-1541
Number of pages5
JournalJournal of Immunology
Volume187
Issue number4
DOIs
StatePublished - Aug 15 2011
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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