Cutting edge: A critical role for IL-10 in induction of nasal tolerance in experimental autoimmune myocarditis

Ziya Kaya, K. Malte Dohmen, Yan Wang, Jens Schlichting, Marina Afanasyeva, Florian Leuschner, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Appropriate treatment of autoimmune myocarditis following virus infection remains a major clinical problem. Induction of nasal tolerance may provide a new approach to treatment. However, the exact mechanism of nasal tolerance is unknown. To assess the mechanism of nasal tolerance, we examined the role of IL-10 in the induction and suppression of autoimmune myocarditis. First we showed that blocking IL-10 concurrent with nasal administration of Ag abolished the disease-suppressing effect of nasal tolerization. It also led to increased cardiac myosin-specific IL-1 and TNF-α production. Then we demonstrated that blocking IL-10 during the effector phase increased not only the incidence and severity of disease but also Ag-specific IL-2, IL-4, and TNF-α production as well as cardiac myosin-specific IgG1 and IgG2b production, whereas blocking IL-10 during the induction phase had no effect. This study implicates IL-10 in the induction of nasal tolerance and in limiting inflammation later during the disease process.

Original languageEnglish (US)
Pages (from-to)1552-1556
Number of pages5
JournalJournal of Immunology
Volume168
Issue number4
DOIs
StatePublished - Feb 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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