Cutaneous ulceration in dermatomyositis

Association with anti-melanoma differentiation-associated gene 5 antibodies and interstitial lung disease

Neera S. Narang, Livia A Casciola Rosen, Shufeng Li, Lorinda Chung, David F. Fiorentino

Research output: Contribution to journalArticle

Abstract

Objective To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). Methods We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-square or Fisher's exact tests and used univariate and multivariate logistic regression models to assess the association between ulcers and clinical features such as malignancy, interstitial lung disease (ILD), and amyopathic disease. Results Forty-three patients (28%) had cutaneous ulcers. Nearly half the patients had ulcers present in more than 1 location: 24 (56%) had ulcers over the extensor surfaces of joints, 18 (42%) at the digital pulp or periungual areas, and 25 (58%) had ulcers located elsewhere. In univariate analysis ulcers were associated with Asian race, but not with other clinical and demographic features, including malignancy or ILD. In multivariate analysis ulcers were significantly associated with anti-melanoma differentiation gene 5 (anti-MDA5) antibodies (odds ratio 10.14, 95% confidence interval 1.95-52.78; P = 0.0059) and this was greatest for ulcers located at the digital pulp. In patients with cutaneous ulcers, ILD risk was specifically increased only in patients with anti-MDA5-positive antibodies. Conclusion We confirmed the strong association between anti-MDA5 antibodies and cutaneous ulcers, with the novel finding that the association of cutaneous ulcers with ILD depends upon the presence of anti-MDA5 antibodies. DM patients who display this cutaneous phenotype should undergo appropriate evaluation for ILD.

Original languageEnglish (US)
Pages (from-to)667-672
Number of pages6
JournalArthritis Care and Research
Volume67
Issue number5
DOIs
StatePublished - May 1 2015

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Dermatomyositis
Interstitial Lung Diseases
Ulcer
Melanoma
Skin Ulcer
Skin
Antibodies
Genes
Logistic Models
Neoplasms
Multivariate Analysis
Joints
Odds Ratio
Demography
Confidence Intervals
Phenotype

ASJC Scopus subject areas

  • Rheumatology

Cite this

Cutaneous ulceration in dermatomyositis : Association with anti-melanoma differentiation-associated gene 5 antibodies and interstitial lung disease. / Narang, Neera S.; Casciola Rosen, Livia A; Li, Shufeng; Chung, Lorinda; Fiorentino, David F.

In: Arthritis Care and Research, Vol. 67, No. 5, 01.05.2015, p. 667-672.

Research output: Contribution to journalArticle

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