Over the past three decades, there has been a marked increase in the incidence of cutaneous T-cell lymphoma (CTCL), with significant differences in the rates of CTCL by race and ethnicity. The overall incidence of CTCL has been shown to be higher among blacks than among whites and other racial groups. In addition, CTCL is thought to follow a more aggressive course in black patients. This article highlights the differences in clinical appearance and response to therapy, and discusses the differential diagnosis of CTCL in skin of color in an attempt to ensure earlier diagnosis and better outcomes for these patients. Learning objective: After completing this learning activity, participants should be able to recognize and diagnose cutaneous T-cell lymphoma (CTCL) in skin of color, describe the unique aspects of diagnosis and management of CTCL in skin of color, and discuss the differential diagnosis of CTCL.
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