TY - JOUR
T1 - Cutaneous side-effects of biologics in immune-mediated disorders
T2 - A histopathological perspective
AU - Succaria, Farah
AU - Bhawan, Jag
N1 - Publisher Copyright:
© 2017 Japanese Dermatological Association
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.
AB - Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.
KW - biologics
KW - drug reactions
KW - lichen planus
KW - psoriasis
KW - tumor necrosis factor-α inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85014086707&partnerID=8YFLogxK
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U2 - 10.1111/1346-8138.13762
DO - 10.1111/1346-8138.13762
M3 - Review article
C2 - 28256759
AN - SCOPUS:85014086707
SN - 0385-2407
VL - 44
SP - 243
EP - 250
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 3
ER -