Cutaneous side-effects of biologics in immune-mediated disorders: A histopathological perspective

Farah Succaria, Jag Bhawan

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Advances in understanding molecular mechanisms and targets in immune regulation have led to the widespread use of biologic targeted therapies, and, as such, reformed the course of many disabling diseases. However, with their expanded use, various side-effects, including cutaneous, have emerged. Many times a clear-cut relationship exists between the drug and the clinical manifestations; however, when a biopsy is warranted, various histopathological patterns may be observed and may cause confusion to the dermatopathologist. The aim of this review is to shed light on the different histopathological patterns observed as a manifestation secondary to biologics.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalJournal of Dermatology
Issue number3
StatePublished - Mar 1 2017
Externally publishedYes


  • biologics
  • drug reactions
  • lichen planus
  • psoriasis
  • tumor necrosis factor-α inhibitors

ASJC Scopus subject areas

  • Dermatology


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