TY - JOUR
T1 - Cutaneous Polyarteritis Nodosa
T2 - Report of a Case Associated with Crohn's Disease
AU - Goslen, J. Blake
AU - Graham, Walter
AU - Lazarus, Gerald S.
PY - 1983/4
Y1 - 1983/4
N2 - A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.
AB - A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.
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U2 - 10.1001/archderm.1983.01650280054016
DO - 10.1001/archderm.1983.01650280054016
M3 - Article
C2 - 6132589
AN - SCOPUS:0020662272
SN - 0003-987X
VL - 119
SP - 326
EP - 329
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 4
ER -