Cutaneous manifestations in neuro-oncology

Clinically relevant tumor and treatment associated dermatologic findings

Roy E. Strowd, Lindsay C. Strowd, Jaishri Blakeley

Research output: Contribution to journalArticle

Abstract

Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.

Original languageEnglish (US)
JournalSeminars in Oncology
DOIs
StateAccepted/In press - 2016

Fingerprint

Skin Manifestations
Skin
Nervous System Neoplasms
Neoplasms
Neurofibromatosis 1
Nervous System
Therapeutics
Neurofibromatosis 2
Paraneoplastic Syndromes
Tuberous Sclerosis
Peripheral Nervous System
Pruritus
Brain Neoplasms
Spine
Drug Therapy

Keywords

  • Brachioradial pruritus
  • Dermatomyositis
  • Neuro-oncology
  • Neurofibromatosis
  • Neuropathic itch
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

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title = "Cutaneous manifestations in neuro-oncology: Clinically relevant tumor and treatment associated dermatologic findings",
abstract = "Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.",
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AU - Strowd, Lindsay C.

AU - Blakeley, Jaishri

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N2 - Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.

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