TY - JOUR
T1 - Cutaneous manifestations in neuro-oncology
T2 - Clinically relevant tumor and treatment associated dermatologic findings
AU - Strowd, Roy E.
AU - Strowd, Lindsay C.
AU - Blakeley, Jaishri O.
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.
AB - Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.
KW - Brachioradial pruritus
KW - Dermatomyositis
KW - Neuro-oncology
KW - Neurofibromatosis
KW - Neuropathic itch
KW - Tuberous sclerosis
UR - http://www.scopus.com/inward/record.url?scp=84962013968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962013968&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2016.02.029
DO - 10.1053/j.seminoncol.2016.02.029
M3 - Review article
C2 - 27178695
AN - SCOPUS:84962013968
SN - 0093-7754
VL - 43
SP - 401
EP - 407
JO - Seminars in oncology
JF - Seminars in oncology
IS - 3
ER -