Cutaneous manifestations in leukemia patients

Michael R. Grunwald, Megan H. McDonnell, Raghava Induru, Jonathan M. Gerber

Research output: Contribution to journalReview articlepeer-review

Abstract

Cutaneous complications are common in patients with leukemia. However, the cause is not always immediately clear, as there are often numerous potential etiologies. Thrombocytopenia or coagulopathy can result in ecchymoses or petechiae, whereas extramedullary (EM) involvement by leukemia can present as a rash. Leukemia can also result in skin manifestations via indirect means, including several types of paraneoplastic phenomena. Moreover, various agents routinely used to treat leukemia - most notably cytarabine (cytosine arabinoside) - can precipitate quite profound skin eruptions. Finally, infections, including fungal invasion of the skin, can be responsible for rashes, as can the vast array of antimicrobials that are administered to leukemia patients.

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalSeminars in oncology
Volume43
Issue number3
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Keywords

  • Extramedullary leukemia
  • Granulocytic sarcoma
  • Leukemia
  • Leukemia cutis
  • Paraneploastic phenomena

ASJC Scopus subject areas

  • Hematology
  • Oncology

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