TY - JOUR
T1 - Cutaneous malignant melanoma and familial dysplastic nevi
T2 - Evidence for autosomal dominance and pleiotropy
AU - Bale, S. J.
AU - Chakravarti, A.
AU - Greene, M. H.
PY - 1986
Y1 - 1986
N2 - Segregation of familial cutaneous melanoma has been shown to be compatible with autosomal dominant transmission with incomplete penetrance. However, the combined phenotype of melanoma and a known melanoma-precursor lesion, the dysplastic nevus (DN), has not previously been found to fit a Mendelian model of inheritance using complex segregation analysis. Employing a life-table and disease-free survival analysis approach, we estimated the lifetime incidence of melanoma in the sibs and offspring of DN-affected individuals to be 46%, consistent with a highly penetrant, autosomal dominant mode of inheritance. To further elucidate the relationship between the two traits, we conducted a linkage analysis between the melanoma locus and a hypothetical DN locus, and obtained a maximum lod score of 3.857 at θ = .08. Furthermore, all families giving evidence for linkage were in the coupling phase and the maximum likelihood estimate of θ was not significantly different from O (P = .1). This provides evidence that the DN and melanoma traits may represent pleiotropic effects of a single, highly penetrant gene behaving in an autosomal dominant manner.
AB - Segregation of familial cutaneous melanoma has been shown to be compatible with autosomal dominant transmission with incomplete penetrance. However, the combined phenotype of melanoma and a known melanoma-precursor lesion, the dysplastic nevus (DN), has not previously been found to fit a Mendelian model of inheritance using complex segregation analysis. Employing a life-table and disease-free survival analysis approach, we estimated the lifetime incidence of melanoma in the sibs and offspring of DN-affected individuals to be 46%, consistent with a highly penetrant, autosomal dominant mode of inheritance. To further elucidate the relationship between the two traits, we conducted a linkage analysis between the melanoma locus and a hypothetical DN locus, and obtained a maximum lod score of 3.857 at θ = .08. Furthermore, all families giving evidence for linkage were in the coupling phase and the maximum likelihood estimate of θ was not significantly different from O (P = .1). This provides evidence that the DN and melanoma traits may represent pleiotropic effects of a single, highly penetrant gene behaving in an autosomal dominant manner.
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M3 - Article
C2 - 3456198
AN - SCOPUS:0022542636
SN - 0002-9297
VL - 38
SP - 188
EP - 196
JO - American journal of human genetics
JF - American journal of human genetics
IS - 2
ER -