Cutaneous malignant melanoma after Hodgkin's disease

M. A. Tucker, D. Misfeldt, C. N. Coleman, W. H. Clark, S. A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Eight cutaneous malignant melanomas occurred in 6 of 1405 patients with Hodgkin's disease, although the expected incidence rate was 0.77 (relative risk, 8; 95% confidence interval, 3 to 17). One melanoma was a thin, level II lesion less than 0.76 mm thick; the rest were mostly bulky, deeply invasive lesions despite close clinical surveillance. The melanomas spread aggressively; 3 of 6 patients died within 1 to 3 years. Two of the six patients developed a second primary malignant melanoma 1 year after the first. Two of six patients had biopsy-proven dysplastic nevus syndrome, a known precursor to cutaneous malignant melanoma, and an additional 3 patients had clinical evidence of dysplastic nevus syndrome. Histologically, the malignant melanomas showed a sparse inflammatory infiltrate, an abnormal host response seen previously in cutaneous melanomas developing in immunosuppressed patients. Dysplastic nevi may identify patients at highest risk who require modified medical management.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalAnnals of Internal Medicine
Volume102
Issue number1
StatePublished - 1985
Externally publishedYes

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Hodgkin Disease
Dysplastic Nevus Syndrome
Melanoma
Cutaneous Malignant Melanoma
Confidence Intervals
Biopsy
Skin
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tucker, M. A., Misfeldt, D., Coleman, C. N., Clark, W. H., & Rosenberg, S. A. (1985). Cutaneous malignant melanoma after Hodgkin's disease. Annals of Internal Medicine, 102(1), 37-41.

Cutaneous malignant melanoma after Hodgkin's disease. / Tucker, M. A.; Misfeldt, D.; Coleman, C. N.; Clark, W. H.; Rosenberg, S. A.

In: Annals of Internal Medicine, Vol. 102, No. 1, 1985, p. 37-41.

Research output: Contribution to journalArticle

Tucker, MA, Misfeldt, D, Coleman, CN, Clark, WH & Rosenberg, SA 1985, 'Cutaneous malignant melanoma after Hodgkin's disease', Annals of Internal Medicine, vol. 102, no. 1, pp. 37-41.
Tucker MA, Misfeldt D, Coleman CN, Clark WH, Rosenberg SA. Cutaneous malignant melanoma after Hodgkin's disease. Annals of Internal Medicine. 1985;102(1):37-41.
Tucker, M. A. ; Misfeldt, D. ; Coleman, C. N. ; Clark, W. H. ; Rosenberg, S. A. / Cutaneous malignant melanoma after Hodgkin's disease. In: Annals of Internal Medicine. 1985 ; Vol. 102, No. 1. pp. 37-41.
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